Informace o projektu
Next Generation Sequencing Platform for Targeted Personalized Therapy of Leukemia
(NGS-PTL)
- Kód projektu
- 7E13008
- Období řešení
- 9/2013 - 10/2015
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Podpora projektů sedmého rámcového programu Evropského společenství pro výzkum, technologický rozvoj a demonstrace (2007 až 2013)
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
This project aims at developing a European Hematological/HTS platform of scientists for improving outcomes for therapeutic interventions on acute and chronic leukemias and at develop strategies to personalize treatments and tailor therapies to different stratified groups of leukemia patients, with the goal of optimizing their efficacy and safety through a deeper and deeper understanding of the influence of genetic/genomic alterations on leukemias pathogenesis and treatment response (i.e. “personalized therapy”). Moreover, the final aim will be the identification of novel prognostic biomarkers for acute and chronic leukemias, as well as of molecular biomarkers and/or genomic profiles for the assessment of minimal residual disease. The originality of this project is to perform systematic deep genomic/transcriptomic studies on well-clinically-characterized leukemia patients, by exploiting HTS technologies able to quickly produce data with a good cost-effectiveness and an unprecedented resolution.
Publikace
Počet publikací: 23
2019
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CLL cells cumulate genetic aberrations prior to the first therapy even in outwardly inactive disease phase
Leukemia, rok: 2019, ročník: 33, vydání: 2, DOI
2017
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Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
Oncotarget, rok: 2017, ročník: 8, vydání: 41, DOI
2016
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A role for palindromic structures in the cis-region of maize Sirevirus LTRs in transposable element evolution and host epigenetic response
Genome research, rok: 2016, ročník: 26, vydání: 2, DOI
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Analysis of clonal evolution in chronic lymphocytic leukemia from inactive to symptomatic disease prior treatment using whole-exome sequencing.
Rok: 2016, druh: Konferenční abstrakty
2015
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13Q deletion in predominant cytogenetic aberration newly aquired during chronic lymohocytic leukemia course irrespective of disease activity and treatment status.
Rok: 2015, druh: Konferenční abstrakty
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Analysis of Prognostic Significance of Merkel Cell Polyomavirus in Chronic Lymphocytic Leukemia
Clinical Lymphoma Myeloma & Leukemia, rok: 2015, ročník: 15, vydání: 7, DOI
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ARResT/AssignSubsets: a novel application for robust subclassification of chronic lymphocytic leukemia based on B cell receptor IG stereotypy
Bioinformatics, rok: 2015, ročník: 31, vydání: 23, DOI
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B-cell receptor signalling and its crosstalk with other pathways in normal and malignant cells
European Journal of Haematology, rok: 2015, ročník: 94, vydání: 3, DOI
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Detailed analysis of therapy-driven clonal evolution of TP53 mutations in chronic lymphocytic leukemia
Leukemia, rok: 2015, ročník: 29, vydání: 4, DOI
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Detection of Minimal Residual Disease in Mantle Cell Lymphoma. Establishment of Novel Eight-Color Flow Cytometry Approach
Cytometry Part B: Clinical Cytometry, rok: 2015, ročník: 88, vydání: 2, DOI