Informace o projektu
Amphiphilic Peptides at Phospholipid Membranes
- Kód projektu
- GA17-11571S
- Období řešení
- 1/2017 - 12/2019
- Investor / Programový rámec / typ projektu
-
Grantová agentura ČR
- Standardní projekty
- Fakulta / Pracoviště MU
- Středoevropský technologický institut
Phospholipid membranes are a vital component of all cells, with a semipermeable barrier function, which can be altered by interaction with amphiphilic peptides. In particular, antimicrobial and cell-penetrating peptides are of high importance due to their potential medical and biochemical applications. Despite progress in the insight of their behavior, we still lack a full understanding of the membrane permeation or crossing by these peptides. Using computer simulations with coarse-grained models, we propose to: 1) determine the effect of a peptide kink on translocation and pore formation, 2) derive a theory to connect the peptide molecular properties with macroscopic effects of pore formation and translocation, and 3) evaluated the role of lipid compositions of the membrane on different permeabilization mechanisms. The obtained understanding of peptide behavior at the membrane will be useful for the rational design of peptides more effective and specific against target cells or bacteria.
Publikace
Počet publikací: 12
2021
-
Enhanced translocation of amphiphilic peptides across membranes by transmembrane proteins.
Biophysical Journal, rok: 2021, ročník: 120, vydání: 11, DOI
-
Phosphorylation-induced changes in the PDZ domain of Dishevelled 3
Scientific Reports, rok: 2021, ročník: 11, vydání: 1, DOI
-
Selecting Collective Variables and Free Energy Methods for Peptide Translocation Across Membranes.
Journal of Chemical Information and Modeling, rok: 2021, ročník: 61, vydání: 2, DOI
2020
-
Effect of helical kink in antimicrobial peptides on membrane pore formation
eLife, rok: 2020, ročník: 9, vydání: March 2020, DOI
-
Effect of Helical Kink on Peptide Translocation across Phospholipid Membranes
The Journal of Physical Chemistry B, rok: 2020, ročník: 124, vydání: 28, DOI
-
Effect of membrane composition on DivIVA-membrane interaction.
BBA Biomembranes, rok: 2020, ročník: 1862, vydání: 8, DOI
-
Magainin 2 and PGLa in Bacterial Membrane Mimics II: Membrane Fusion and Sponge Phase Formation.
Biophysical Journal, rok: 2020, ročník: 118, vydání: 3, DOI
2019
-
Force Field Comparison of GM1 in a DOPC Bilayer Validated with AFM and FRET Experiments.
JOURNAL OF PHYSICAL CHEMISTRY B, rok: 2019, ročník: 123, vydání: 35, DOI
-
Magainin 2 and PGLa in Bacterial Membrane Mimics I: Peptide-Peptide and Lipid-Peptide Interactions.
Biophysical Journal, rok: 2019, ročník: 117, vydání: 10, DOI
2018
-
Implementing efficient concerted rotations using Mathematica and C code
EUROPEAN PHYSICAL JOURNAL E, rok: 2018, ročník: 41, vydání: 7, DOI