Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 182
2022
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The role of bivalent ions in the regulation of D-loop extension mediated by DMC1 during meiotic recombination
iSCIENCE, rok: 2022, ročník: 25, vydání: 11, DOI
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To homodimerize or to heterodimerize: story of 14-3-3 protein dimer formation
Rok: 2022, druh: Konferenční abstrakty
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XXXIV/252. Mass spectrometry analysis of extracellular vesicles from malignant ascites highlights the role of tumor microenvironment in progression of ovarian cancer
Rok: 2022, druh: Konferenční abstrakty
2021
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14-3-3ζ phosphomimicking mutants: an alternative to phosphorylation?
Študentská vedecká konferencia PriF UK 2021: zborník recenzovaných príspevkov, rok: 2021
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Alkaloid Escholidine and Its Interaction with DNA Structures
BIOLOGY-BASEL, rok: 2021, ročník: 10, vydání: 12, DOI
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An introduction to MMS
Rok: 2021, druh: Uspořádání workshopu
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Atomic force microscopy and surface plasmon resonance for real-time single-cell monitoring of bacteriophage-mediated lysis of bacteria
Nanoscale, rok: 2021, ročník: 13, vydání: 31, DOI
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BIO-APPLICABLE METAL NANOPARTICLES
CONFERENCE PROCEEDINGS - NANOCON 2020, rok: 2021
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Business Research Forum
Rok: 2021, druh: Popularizační texty
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Cell based AFM biosensensing for screening of pulmonary-drug related arrhytmic effects
Nanocon 2020, rok: 2021