Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2018127
- Období řešení
- 1/2020 - 12/2022
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
- Spolupracující organizace
-
Biotechnologický ústav AV ČR, v.v.i.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies, will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB is a part of the ESFRI project INSTRUCT-ERIC.
Cíle udržitelného rozvoje
Masarykova univerzita se hlásí k cílům udržitelného rozvoje OSN, jejichž záměrem je do roku 2030 zlepšit podmínky a kvalitu života na naší planetě.
Publikace
Počet publikací: 182
2021
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Structure of the dihydrolipoamide succinyltransferase (E2) component of the human alpha-ketoglutarate dehydrogenase complex (hKGDHc) revealed by cryo-EM and cross-linking mass spectrometry: Implications for the overall hKGDHc structure
Biochimica et Biophysica Acta - General Subjects, rok: 2021, ročník: 1865, vydání: 6, DOI
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Supramolecular hydrogelation via host-guest anion recognition: Lamellar hydrogel materials for the release of cationic cargo
CHEM, rok: 2021, ročník: 7, vydání: 9, DOI
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Synthesis and characterization of WS2/SiO2 microfibers
Journal of Materials Science, rok: 2021, ročník: 56, vydání: 18, DOI
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Synthesis of high surface area aluminophosphate and -phosphonate xerogels by non-hydrolytic sol-gel reactions
Microporous and Mesoporous Materials, rok: 2021, ročník: 311, vydání: February 2021, DOI
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TIME-LAPSE MONITORING OF CELL MECHANICAL PROPERTIES
CONFERENCE PROCEEDINGS - NANOCON 2020, rok: 2021
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Unique electrochemical properties of polymer pencil graphite leads
Rok: 2021, druh: Konferenční abstrakty
2020
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A Model of Aerobic and Anaerobic Metabolism of Hydrogen in the Extremophile Acidithiobacillus ferrooxidans
Frontiers in Microbiology, rok: 2020, ročník: 11, vydání: November 2020, DOI
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Cell type specific adhesion to surfaces functionalised by amine plasma polymer
Scientific Reports, rok: 2020, ročník: 10, vydání: 1, DOI
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Combination of biophysical techniques for protein characterization – a case study of Aspergillus fumigatus lectin
Rok: 2020, druh: Konferenční abstrakty
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Competitive upconversion-linked immunoassay using peptide mimetics for the detection of the mycotoxin zearalenone
Biosensors and Bioelectronics, rok: 2020, ročník: 170, vydání: December 2020, DOI