Informace o projektu
Design, synthesis and evaluation of potential metalloenzymes inhibitors
(DSEPMI)
- Kód projektu
- MUNI/IGA/1339/2021
- Období řešení
- 1/2022 - 12/2022
- Investor / Programový rámec / typ projektu
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Masarykova univerzita
- Interní grantová agentura MU
- Fakulta / Pracoviště MU
- Farmaceutická fakulta
Metalloproteins are enzymes that need metal ions to function correctly. Most of them play a crucial role in metabolically essential processes. Due to this reason, they also make them important factors in the progression of many diseases. Pathologies for which metalloenzymes are implicated include cancer, heart disease, and HIV/AIDS. The main goal of this project is to synthesize new series of potential metalloprotein inhibitors and determination of their biological activity.
Publikace
Počet publikací: 4
2023
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Synthesis and evaluation biological activity of newly designed hydroxamates as potential HDAC inhibitors
Rok: 2023, druh: Další prezentace na konferencích
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Synthesis and evaluation of biological activity of newly designed hydroxamates as potential HDAC inhibitors
Rok: 2023, druh: Další prezentace na konferencích
2022
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DESIGN AND SYNTHESIS OF N-HYDROXY-CINNAMAMIDE DERIVATES AS NOVEL HDAC INHIBITORS: EVALUATION OF BIOLOGICAL ACTIVITY IN CANCER CELLS
Czech Chemical Society Symposium Series, rok: 2022
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TARGETING METALLOENZYMES WITH NEWLY DESIGNED INHIBITORS FOR POTENTIAL THERAPEUTIC INTERVENTION
Rok: 2022, druh: Další prezentace na konferencích