Informace o projektu
Characterization of the RAD51 role in TERRA recruitment to telomere

Telomeric repeat containing RNA (TERRA) was revealed to be recruited to telomeres by RAD51 protein by the mechanism resembling strand-invasion and homology-search mechanism utilized in homology directed DNA repair (HDR). However, detailed mechanism of TERRA recruitment remains uncovered. We would like to focus on biochemical characterization of RAD51-TERRA interaction and regulation of TERRA recruitment.