Informace o projektu
COUNTER-ACTING THE PANDEMIC POTENTIAL OF FLAVIVIRUSES: ADDRESSING VIRUS-HOST INTERACTION AND DEFENSE STRATEGIES TO DESIGN NEW THERAPEUTICS AGAINST WNV AND DENV (InFlaMe)

O1. To identify virological, immunological and human genetic risk factors associated with severe flavivirus infections (WP2), with a major focus on West Nile Virus (WNV) and Dengue virus (DENV);
O2. To measure the humoral immune response against viral infections with a strong focus on monoclonal antibody selection and characterization (WP3);
O3. To define the phenotype and functional role of T-cell response in flavivirus infection and pathogenesis (WP4);
O4. To identify and characterize viral-host interaction for the design and synthesis of host-viral protein binding inhibitors (WP5);
O5. To establish the impact of climate changes on flavivirus epidemiology in both human and animal settings for a “One Health” approach of surveillance (WP6).