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A new F-actin structure in fungi: actin ring formation around the cell nucleus of Cryptococcus neoformans

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KOPECKÁ Marie KAWAMOTO Susumu YAMAGUCHI Masashi

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj Journal of Electron Microscopy
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1093/jmicro/dfs074
Obor Genetika a molekulární biologie
Klíčová slova perinuclear F-actin ring; nucleus; Cryptococcus neoformans
Přiložené soubory
Popis The F-actin cytoskeleton of Cryptococcus neoformans is known to comprise actin cables, cortical patches and cytokinetic ring. Here, we describe a new F-actin structure in fungi, a perinuclear F-actin collar ring around the cell nucleus, by fluorescent microscopic imaging of rhodamine phalloidin-stained F-actin. Perinuclear F-actin rings form in Cryptococcus neoformans treated with the microtubule inhibitor Nocodazole or with the drug solvent dimethyl sulfoxide (DMSO) or grown in yeast extract peptone dextrose (YEPD) medium, but they are absent in cells treated with Latrunculin A. Perinuclear F-actin rings may function as ‘funicular cabin’ for the cell nucleus, and actin cables as intracellular ‘funicular’ suspending nucleus in the central position in the cell and moving nucleus along the polarity axis along actin cables.
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