Informace o publikaci

Effect of a selective progesterone receptor modulator on induction of apoptosis in uterine fibroids in vivo

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HORÁK Petr MÁRA Michal DUNDR Pavel KUBÍNOVÁ Kristýna KUŽEL David HUDEČEK Robert CHMEL Roman

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj International Journal of Endokrinology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1155/2012/436174
Obor Gynekologie a porodnictví
Klíčová slova LOW-DOSE MIFEPRISTONE; MENSTRUAL BLOOD-LOSS; ULIPRISTAL ACETATE; MEDICAL-TREATMENT; ASOPRISNIL J867; LEIOMYOMA CELLS; EXPRESSION; GROWTH; PROLIFERATION; THERAPY
Přiložené soubory
Popis Aim. To determine if hormonal treatment induces apoptosis in uterine fibroids. Methods. Immunohistochemical examination of fibroid tissue, using avidin-biotin complex and cleaved caspase-3 antibody for detecting apoptosis, was performed in premenopausal women who underwent 12-week treatment with oral SPRM (6 patients with 5 mg and 5 patients with 10 mg of ulipristal acetate per day) or gonadoliberin agonist (GnRHa, 17 patients) and subsequent myomectomy or hysterectomy for symptomatic uterine fibroids. Ten patients with no presurgical hormonal treatment were used as controls. Results. Apoptosis was present in a significantly higher proportion of patients treated with ulipristal acetate compared to GnRHa (P = 0.01) and to patients with no hormonal treatment (P = 0.01). In contrast to an AI of 158.9 in SPRM patients, the mean AI was 27.5 and 2.0 in GnRHa and control groups, respectively. No statistical difference in the AI was observed between the two groups of patients treated with ulipristal acetate (5 mg or 10 mg). Conclusion. Treatment with ulipristal acetate induces apoptosis in uterine fibroid cells. This effect of SPRM may contribute to their positive clinical effect on uterine fibroids.

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