Informace o publikaci

Skin toxicity and efficacy of sunitinib and sorafenib in metastatic renal cell carcinoma: a national registry-based study

Autoři

POPRACH Alexandr PAVLÍK Tomáš MELICHAR Bohuslav PUZANOV Igor DUŠEK Ladislav BORTLÍČEK Zbyněk VYZULA Rostislav ABRAHÁMOVÁ Jitka BÜCHLER Tomáš

Rok publikování 2012
Druh Článek v odborném periodiku
Časopis / Zdroj Annals of Oncology
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://annonc.oxfordjournals.org/content/early/2012/06/13/annonc.mds145.abstract
Doi http://dx.doi.org/10.1093/annonc/mds145
Obor Onkologie a hematologie
Klíčová slova hand–foot syndrome; rash; renal cell cancer; sorafenib; sunitinib; survival
Popis Background: A retrospective, registry-based analysis to assess the outcomes of metastatic renal cell cancer (mRCC) patients treated with sunitinib and sorafenib who developed dermatologic adverse events was performed. Patients and Methods: Data on mRCC patients treated with sunitinib or sorafenib were obtained from the Czech Clinical Registry of Renal Cell Cancer Patients. Outcomes of patients who developed hand–foot syndrome (HFS) of any grade and/or grade 3/4 rash during the treatment were compared with patients without HFS and no, mild, or moderate rash. Results: The cohort included 705 patients treated with sunitinib and 365 patients treated with sorafenib. For sunitinib, the median overall survival (OS) was 43.0 months versus 31.0 months (P = 0.027) and median progression-free survival (PFS) 20.8 months versus 11.1 months (P = 0.007) for patients with versus without dermatologic toxicity, respectively. For sorafenib, the median OS and PFS were 27.9 and 24.6 months (P = 0.244), and 12.2 and 8.8 months (P = 0.050), respectively. In multivariable Cox regression, the skin toxicity was significantly associated with longer OS in the sunitinib cohort. Conclusion: The presence of skin toxicity is associated with improved OS and PFS in patients with mRCC treated with sunitinib.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info