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Analysis of selected miRNAs in glioblastoma stem cells

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KLEINOVÁ Renata ŠÁNA Jiří DULAVOVÁ Eva KŘEN Leoš FADRUS Pavel SLABÝ Ondřej

Rok publikování 2013
Druh Konferenční abstrakty
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
Popis Glioblastoma multiforme (GBM) is the most frequent malignant brain tumor characterized by very poor prognosis. Despite a treatment based on maximal surgical resection followed by concomitant chemoradiotherapy with temozolomide and adjuvant temozolomide, the median of overall survival is less than 15 months from diagnosis. This is caused by a high resistance to the therapy that is attributed to small subpopulation of glioblastoma stem cells. Similar like non-cancer neuronal stem cells, they express markers of undifferentiated stem cell such as CD133. MicroRNAs are small, non-coding RNAs that function as post-transcription regulators of gene expression. Therefore, they play also key role in maintaining of glioblastoma stem cells phenotype including a resistance to the chemoradiotherapy.
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