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Informace o publikaci
Human Vdelta1 gamma-delta T cells exert potent specific cytotoxicity against primary multiple myeloma cells
Autoři | |
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Rok publikování | 2012 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Cytotherapy |
Fakulta / Pracoviště MU | |
Citace | |
www | http://informahealthcare.com/doi/abs/10.3109/14653249.2012.700766 |
Doi | http://dx.doi.org/10.3109/14653249.2012.700766 |
Obor | Onkologie a hematologie |
Klíčová slova | cytotoxicity; flow cytometry; gamma-delta cells; immunotherapy; multiple myeloma |
Přiložené soubory | |
Popis | Human gamma-delta (gamma-delta) T cells are potent effector lymphocytes of innate immunity involved in anti-tumor immune surveillance. However, the Vdelta1 gamma-delta T-cell subset targeting multiple myeloma (MM) has not previously been investigated. We have shown for the first time that Vdelta1 T cells are highly myeloma-reactive and have therefore established Vdelta1 gamma-delta T cells as a potential candidate for a novel tumor immunotherapy. |