Informace o publikaci
Assessment and modulation of doxorubicin cytotoxicity
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Rok publikování | 2013 |
Druh | Konferenční abstrakty |
Citace | |
Popis | In our study we focused on cytotoxicity of doxorubicin, epirubicin, apodox (apoferritin filled with doxorubicin), and two liposomal forms of doxorubicin (liposome-8 and myocet) for prostate cell lines by using MTT assay and the xCELLigence system (impedance-based method). Three different prostatic cell lines were chosen as a model of prostate cancer (PC-3, LNCaP, and 22Rv1). One prostatic cell line PNT1A was chosen as a model of healthy prostatic tissue. We confirmed the lower toxicity of apodox, liposome-8, and myocet as compared with doxorubicin and epirubicin.In addition, liposome-8 also seems to be more toxic for cancer cells than for healthy prostatic cell line PNT1A. |