Informace o publikaci
Assessment and modulation of doxorubicin cytotoxicity
| Autoři | |
|---|---|
| Rok publikování | 2013 |
| Druh | Konferenční abstrakty |
| Citace | GUMULEC, Jaromír a Michal MASAŘÍK. Assessment and modulation of doxorubicin cytotoxicity. In XIII. Pracovní setkání fyzikálních chemiků a elektrochemiků. 2013. |
| Popis | In our study we focused on cytotoxicity of doxorubicin, epirubicin, apodox (apoferritin filled with doxorubicin), and two liposomal forms of doxorubicin (liposome-8 and myocet) for prostate cell lines by using MTT assay and the xCELLigence system (impedance-based method). Three different prostatic cell lines were chosen as a model of prostate cancer (PC-3, LNCaP, and 22Rv1). One prostatic cell line PNT1A was chosen as a model of healthy prostatic tissue. We confirmed the lower toxicity of apodox, liposome-8, and myocet as compared with doxorubicin and epirubicin.In addition, liposome-8 also seems to be more toxic for cancer cells than for healthy prostatic cell line PNT1A. |