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Assessment and modulation of doxorubicin cytotoxicity

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GUMULEC Jaromír MASAŘÍK Michal

Rok publikování 2013
Druh Konferenční abstrakty
Citace
Popis In our study we focused on cytotoxicity of doxorubicin, epirubicin, apodox (apoferritin filled with doxorubicin), and two liposomal forms of doxorubicin (liposome-8 and myocet) for prostate cell lines by using MTT assay and the xCELLigence system (impedance-based method). Three different prostatic cell lines were chosen as a model of prostate cancer (PC-3, LNCaP, and 22Rv1). One prostatic cell line PNT1A was chosen as a model of healthy prostatic tissue. We confirmed the lower toxicity of apodox, liposome-8, and myocet as compared with doxorubicin and epirubicin.In addition, liposome-8 also seems to be more toxic for cancer cells than for healthy prostatic cell line PNT1A.

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