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Predictive and prognostic significance of sodium levels in patients with NSCLC treated by Erlotinib

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SVATON Martin FIALA Ondrej PESEK Milos BRUHA Frantisek MUKENSNABL Petr RACEK Jaroslav MINARIK Marek BORTLÍČEK Zbyněk

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj Anticancer Research
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Obor Onkologie a hematologie
Klíčová slova Hyponatremia; NSCLC; OS; PFS; Predictive marker; Prognosis
Popis Background: Hyponatremia is a well-known phenomenon in cancer patients. The aim of our retrospective study was to assess the relationship of natremia levels to predict treatment with erlotinib and also to assess the prognosis of patients with hyponatremia. Patients and Metods: We analyzed data of 544 patients with advancedstage non-small cell lung cancer (NSCLC) treated with erlotinib. Results: Hyponatremia was measured in 21.5 % of patients before treatment with erlotinib. We found a significant increase in the effectiveness of treatment with erlotinib in patients with normal levels of sodium to hyponatremic patients. Progression-free survival (PFS) and overall survival (OS) were also significantly higher in patients with normal natremia. Multivariate Cox model analysis demonstrated that natremia was an independent factor for PFS and OS. Conslusion: We reported hyponatremia not only as a prognostic marker in NSCLC patients but also as predictive marker of erlotinib treatment efficacy, being an independent factor at the present large retrospective study. Its possible effect in clinical practice is bigger thanks the simple possibility of testing of hyponatremia and the low cost of this biomarker.

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