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Odor Identification in Frontotemporal Lobar Degeneration Subtypes

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MAGEROVA Hana VYHNALEK Martin LACZO Jan ANDEL Ross REKTOROVÁ Irena KADLECOVA Alexandra BOJAR Martin HORT Jakub

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj American Journal of Alzheimer's Disease and other Dementias
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1177/1533317514539033
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova odor identification; behavioral variant frontotemporal dementia; primary nonfluent aphasia; semantic dementia; progressive supranuclear palsy; cognitive status
Popis Odor identification impairment is a feature of several neurodegenerative disorders. Although neurodegenerative changes in the frontotemporal lobar degeneration (FTLD) subtypes involve areas important for olfactory processing, data on olfactory function in these patients are limited. An 18-item, multiple-choice odor identification test developed at our memory clinic, the Motol Hospital smell test, was administered to 9 patients with behavioral variant frontotemporal dementia, 13 patients with the language variants, primary nonfluent aphasia (n = 7) and semantic dementia (n = 6), and 8 patients with progressive supranuclear palsy. Compared to the control group (n = 15), all FTLD subgroups showed significant impairment of odor identification (P < .05). The differences between the FTLD subgroups were not significant. No correlation between odor identification and neuropsychological tests results was found. Our data suggest that odor identification impairment is a symptom common to FTLD syndromes, and it seems to be based on olfactory structure damage rather than cognitive decline.

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