Informace o publikaci

Sensory disturbances, inhibitory deficits, and the P50 wave in schizophrenia

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VLČEK Přemysl BOB Petr RABOCH Jiří

Rok publikování 2014
Druh Článek v odborném periodiku
Časopis / Zdroj NEUROPSYCHIATRIC DISEASE AND TREATMENT
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.dovepress.com/sensory-disturbances-inhibitory-deficits-and-the-p50-wave-in-schizophr-peer-reviewed-article-NDT
Doi http://dx.doi.org/10.2147/NDT.S64219
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova event-related potential; information overload; inhibition; P50 wave; schizophrenia; splitting
Popis Sensory gating disturbances in schizophrenia are often described as an inability to filter redundant sensory stimuli that typically manifest as inability to gate neuronal responses related to the P50 wave, characterizing a decreased ability of the brain to inhibit various responses to insignificant stimuli. It implicates various deficits of perceptual and attentional functions, and this inability to inhibit, or "gate", irrelevant sensory inputs leads to sensory and information overload that also may result in neuronal hyperexcitability related to disturbances of habituation mechanisms. These findings seem to be particularly important in the context of modern electrophysiological and neuroimaging data suggesting that the filtering deficits in schizophrenia are likely related to deficits in the integrity of connections between various brain areas. As a consequence, this brain disintegration produces disconnection of information, disrupted binding, and disintegration of consciousness that in terms of modern neuroscience could connect original Bleuler's concept of "split mind" with research of neural information integration.
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