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Analysis of B-Cell Subpopulations in Monoclonal Gammopathies
Autoři | |
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Rok publikování | 2015 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Clinical Lymphoma Myeloma & Leukemia |
Fakulta / Pracoviště MU | |
Citace | |
Doi | http://dx.doi.org/10.1016/j.clml.2014.12.003 |
Obor | Onkologie a hematologie |
Klíčová slova | B-cell; Flow Cytometry; Multiple Myeloma; Monoclonal Gammopathy; Plasma Cell |
Popis | To clarify the pathophysiology of multiple myeloma (MM) it is necessary to investigate the various developmental stages of B-cells. We provide a detailed phenotypic profile and enumeration of B-cell subpopulations in monoclonal gammopathy patients. A reduction of B-cells and differentiation shift to more numerous antigenstimulated forms was observed in MM. This might indicate a potential source of myeloma-initiating cells in one of these subpopulations. |
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