False-negative interferon-gamma release assay results in active tuberculosis: a TBNET study

• Autoři: VISSER Veerle de; SOTGIU Viovanni; LANGE Christoph; AABYE Martine G.; BAKKER Marleen; BARTALESI Filippo; BRAT Kristián; CHEE Cynthia B.E.; DHEDA Keertan; DOMINGUEZ Jose; EYUBOGLU Fusun; GHANEM Maha; GOLETTI Delia; DILEKTASLI Asli Gorek; GUGLIELMETTI Lorenzo; KOH Won-Jung; LATORRE Irene; LOSI Monica; POLANOVA Monica; RAVN Pernile; RINGSHAUSEN Felix C.; RUMETSHOFER Rudolf; SOUZA-GALVAO Maria Luiza de; THIJSEN Steven; BOTHAMLEY Graham; BOSSINK Aik
• Rok publikování: 2015
• Druh: Článek v odborném periodiku
• Časopis / Zdroj: European Respiratory Journal
• Fakulta / Pracoviště MU: Lékařská fakulta
• Doi: http://dx.doi.org/10.1183/09031936.00120214
• Obor: Pneumologie
• Klíčová slova: gamma interferon; HLA antigen; major histocompatibility antigen class 2
• Popis: Tuberculosis is one of the leading causes of morbidity and mortality worldwide [1]. Rapid identification of contagious tuberculosis patients and effective treatment are necessary to prevent the spread of Mycobacterium tuberculosis, the causative bacterium of the disease. Although interferon-gamma release assays (IGRAs) have been developed for the diagnosis of latent infection with M. tuberculosis, these assays are sometimes used as adjunctive tests in the diagnostic workup for active tuberculosis, despite poor specificity.