Informace o publikaci
MicroRNAs in urine are not biomarkers of multiple myeloma
| Autoři | |
|---|---|
| Rok publikování | 2015 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Negative Results in BioMedicine |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1186/s12952-015-0035-7 |
| Obor | Onkologie a hematologie |
| Klíčová slova | MicroRNAs; urine; biomarkers; multiple myeloma |
| Přiložené soubory | |
| Popis | Background: In this study, we aimed to identify microRNA from urine of multiple myeloma patients that could serve as a biomarker for the disease. Results: Analysis of urine samples was performed using Serum/Plasma Focus PCR MicroRNA Panel (Exiqon) and verified using individual TaqMan miRNA assays for qPCR. We found 20 deregulated microRNA (p < 0.05); for further validation, we chose 8 of them. Nevertheless, only differences in expression levels of miR-22-3p remained close to statistical significance. Conclusions: Our preliminary results did not confirm urine microRNA as a potential biomarker for multiple myeloma. |