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Electrocardiographic features of disease progression in arrhythmogenic right ventricular cardiomyopathy/dysplasia

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SAGUNER AM GANAHL S KRAUS Andrea BALDINGER SH AKDIS D SAGUNER AR WOLBER T HAEGELI LM STEFFEL J KRASNIQI N LUSCHER TF TANNER FC BRUNCKHORST C DURU F

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj BMC Cardiovascular Disorders
Citace
www http://dx.doi.org/10.1186/1471-2261-15
Doi http://dx.doi.org/10.1186/1471-2261-15
Klíčová slova Arrhythmogenic Right Ventricular; Cardiomyopathy; Dysplasia; Electrocardiography; T wave inversion
Popis Background: Arrhythmogenic right ventricular cardiomyopathy/dysplasia (ARVC/D) is considered a progressive cardiomyopathy. However, data on the clinical features of disease progression are limited. The aim of this study was to assess 12-lead surface electrocardiographic (ECG) changes during long-term follow-up, and to compare these findings with echocardiographic data in our large cohort of patients with ARVC/D. Methods: Baseline and follow-up ECGs of 111 patients from three tertiary care centers in Switzerland were systematically analyzed with digital calipers by two blinded observers, and correlated with findings from transthoracic echocardiography. Results: The median follow-up was 4 years (IQR 1.9-9.2 years). ECG progression was significant for epsilon waves (baseline 14% vs. follow-up 31%, p = 0.01) and QRS duration (111 ms vs. 114 ms, p = 0.04). Six patients with repolarization abnormalities according to the 2010 Task Force Criteria at baseline did not display these criteria at follow-up, whereas in all patients with epsilon waves at baseline these depolarization abnormalities also remained at follow-up. T wave inversions in inferior leads were common (36% of patients at baseline), and were significantly associated with major repolarization abnormalities (p = 0.02), extensive echocardiographic right ventricular involvement (p = 0.04), T wave inversions in lateral precordial leads (p = 0.05), and definite ARVC/D (p = 0.05). Conclusions: Our data supports the concept that ARVC/D is generally progressive, which can be detected by 12-lead surface ECG. Repolarization abnormalities may disappear during the course of the disease. Furthermore, the presence of T wave inversions in inferior leads is common in ARVC/D.

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