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Occupational exposure to endocrine disruptors and lymphoma risk in a multi-centric European study

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COSTAS L. INFANTE-RIVARD C. ZOCK J.P. VAN TONGEREN M. BOFFETTA P. CUSSON A. ROBLES C. CASABONNE D. BENAVENTE Y. BECKER N. BRENNAN P. FORETOVÁ Lenka MAYNADIE M. STAINES A. NIETERS A. COCCO P. SANJOSÉ S. de

Rok publikování 2015
Druh Článek v odborném periodiku
Časopis / Zdroj British journal of cancer
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
Doi http://dx.doi.org/10.1038/bjc.2015.83
Obor Onkologie a hematologie
Klíčová slova endocrine disruptors; chemicals; lymphoma; leukaemia; solvents; pesticides; alkylphenols
Popis Background: Incidence rates of lymphoma are usually higher in men than in women, and oestrogens may protect against lymphoma. Methods: We evaluated occupational exposure to endocrine disrupting chemicals (EDCs) among 2457 controls and 2178 incident lymphoma cases and subtypes from the European Epilymph study. Results: Over 30 years of exposure to EDCs compared to no exposure was associated with a 24% increased risk of mature B-cell neoplasms (P-trend = 0.02). Associations were observed among men, but not women. Conclusions: Prolonged occupational exposure to endocrine disruptors seems to be moderately associated with some lymphoma subtypes.

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