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Amphetamine-related drugs neurotoxicity in humans and in experimental animals: Main mechanisms

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MORATALLA Rosario KHAIRNAR Amit Suresh SIMOLA Nicola GRANADO Noelia GARCIA-MONTES Jose Ruben PORCEDDU Pier Francesca TIZABI Yousef COSTA Giulia MORELLI Micaela

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj PROGRESS IN NEUROBIOLOGY
Fakulta / Pracoviště MU

Středoevropský technologický institut

Citace
www http://www.sciencedirect.com/science/article/pii/S0301008215001008?via%3Dihub
Doi http://dx.doi.org/10.1016/j.pneurobio.2015.09.011
Obor Neurologie, neurochirurgie, neurovědy
Klíčová slova Dopamine; Ecstasy; Methamphetamine; METH; MDMA; Mouse; Neurodegeneration; Neuroinflammation neurotoxicity; Non-human primate; Rat
Popis Amphetamine-related drugs, such as 3,4-methylenedioxymethamphetamine (MDMA) and methamphetamine (METH), are popular recreational psychostimulants. Several preclinical studies have demonstrated that, besides having the potential for abuse, amphetamine-related drugs may also elicit neurotoxic and neuroinflammatory effects. The neurotoxic potentials of MDMA and METH to dopaminergic and serotonergic neurons have been clearly demonstrated in both rodents and nonhuman primates. This review summarizes the species-specific cellular and molecular mechanisms involved in MDMA and METH-mediated neurotoxic and neuroinflammatory effects, along with the most important behavioral changes elicited by these substances in experimental animals and humans. Emphasis is placed on the neuropsychological and neurological consequences associated with the neuronal damage. Moreover, we point out the gap in our knowledge and the need for developing appropriate therapeutic strategies to manage the neurological problems associated with amphetamine-related drug abuse. (C) 2015 Elsevier Ltd. All rights reserved.

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