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Modulation of neutrophil oxidative burst via histamine receptors

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ČÍŽ Milan LOJEK Antonín

Rok publikování 2013
Druh Článek v odborném periodiku
Časopis / Zdroj British Journal of Pharmacology
Citace
Doi http://dx.doi.org/10.1111/bph.12107
Klíčová slova neutrophil; oxidative burst; reactive oxygen species; histamine; histamine receptor
Popis Histamine has the ability to influence the activity of immune cells including neutrophils and plays a pivotal role in inflammatory processes, which are a complex network of cellular and humoral events. One of the main functions manifested by activated neutrophils is oxidative burst, which is linked to the production of reactive oxygen species; therefore, the effects of histamine receptor agonists and antagonists on the oxidative burst of neutrophils is reviewed. A role for the well-characterized histamine H-1 and H-2 receptors in this process is discussed and compared to that of the recently discovered H-4 receptor.

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