Informace o publikaci
NOVEL ORGANOMETALLIC COMPOUNDS AND THEIR EFFECT ON OVARIAN CANCER CELLS
| Název česky | Nové organometalické sloučeniny a jejich účinek na buněčných liniích karcinomu ovaria |
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| Autoři | |
| Rok publikování | 2017 |
| Druh | Konferenční abstrakty |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | Cisplatin is the first ever and substantially successful compound containing the central metal atom in its structure (1). Despite the undeniable success against several types of tumors, cisplatin as well as its derivatives displays a number of grave side effects. A significant problem is also affecting of rapidly dividing non cancerous cells and developing drug resistance during treatment (2). Therefore the current research deals with synthesis and testing of new organometallic compounds containing other metals such as Fe, Ti, Ru, Zr, etc., which may in near future replace chemotherapy based on cisplatin. In this context, we cooperate with several laboratories focused on synthesis of organometallic compounds whose cytotoxicity is further tested on selected ovarian cancer cell lines in our case A2780, A2780cis and SK-OV-3 (3, unpublished data). The most promising substances were selected to study their cumulative ability in the cells and to determine cellular processes responsible for their cellular uptake more in detail. Recently we developed new method based on pulse voltammetry to study amount of particular drugs accumulated in the cells. This data is now compared with ICP-MS method used to determine ferrocenes in the cells. Both methods confirmed elevated levels of iron in tested cancer cells (4, unpublished data). The important part of our work also consist in determination the mode of action of the most active substances towards cancer cells. Our preliminary experiments indicate increased development of oxygen radicals that may represent a major cytotoxic mechanism. |