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Domino synthesis of quinazolin-4-yl thioureido alkanoates

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FATHALLA Walid PAZDERA Pavel

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Chemical Papers
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.1007/s11696-017-0273-x
Doi http://dx.doi.org/10.1007/s11696-017-0273-x
Obor Organická chemie
Klíčová slova Amino acid esters; Chemoselective reactions; Intramolecular hydrogen bond; Domino reaction
Popis A simple convenient protocol for the synthesis of Me 2-[3-(2-(substituted phenyl)quinazolin-4-yl)thioureido] alkanoates I (R1 = H, CH3, OCH3; R2 = H, OCH3; R3 = H, CH3; R4 = H, CH3, CH2CH(CH3)2, C6H5; n = 0, 1, 2) has been described. It involves the domino reaction of various amino acid esters NH2CHR4(CH2)nC(O)OCH3·HCl with imidoylisothiocyanates II in Et acetate to afford quinazoline thiourea derivs. in excellent yields. Short reaction time, mild condition, simple work up, high yields, and pure products are the major advantages of this protocol. The no. of isolated pure compds. from this simple protocol is 24. The starting imidoyl isothiocyanates II were prepd. from the corresponding benzanilides III and purified by flash chromatog.

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