Informace o publikaci

Interaction of nanostructured TiO2 biointerfaces with stern cells and biofilm-forming bacteria

Autoři

KULKARNI M. JUNKAR I. HUMPOLÍČEK Petr CAPAKOVA Z. RADASZKIEWICZ Katarzyna Anna MIKUSOVA N. PACHERNÍK Jiří LEHOCKÝ Marián IGLIC A. HANÁČKOVÁ Markéta MOZETIC M.

Rok publikování 2017
Druh Článek v odborném periodiku
Časopis / Zdroj MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://www.sciencedirect.com/science/article/pii/S0928493116319348?via%3Dihub
Doi http://dx.doi.org/10.1016/j.msec.2017.03.174
Klíčová slova Nanotubes; Titanium; Biofilm; Stem cells; Surface morphology
Popis Nanostructured TiO2 nanotubes (NTs) of diameters from 15 to 100 nm were fabricated by an electrochemical anodization process. Biofilm-positive strains of Bacillus cereus and Pseudomonas aeruginosa behaved similarly on all TiO2 NTs as well as on native titanium (Ti) foil. The adhesion and growth of mesenchymal stem cells (MSc), embryonic stem cells (ESc), and pure cardiomyocytes derived from ESc exhibited significant differences. MSc as well as ESc were, in contrast to cardiomyocytes, able to adhere, and grow on TiO2 NTs. A correlation between NTs diameter and cell behaviour was however observed in the case of MSc and ESc. MSc were not in a physiological state in the case of 100 nm TiO2 NTs, while ESc were not able to grow on 15 nm TiO2 NTs. It can be stated that these differences can be assigned to different diameters of the NTs but not to the chemistry of the surface. This is the first study describing the comprehensive behaviour of both eukaryotic and prokaryotic cells on TiO2 NTs. On the basis of obtained results, it can be concluded that new generation of medical devices providing selective cell behaviour can be fabricated by optimizing the nanoscale morphology of TiO2. (C) 2017 Elsevier B.V. All rights reserved.

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info