Informace o publikaci
Coexistence of gain-of-function JAK2 germ line mutations with JAK2(V617F) in polycythemia vera
| Autoři | |
|---|---|
| Rok publikování | 2016 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Blood |
| Fakulta / Pracoviště MU | |
| Citace | |
| Doi | http://dx.doi.org/10.1182/blood-2016-04-711283 |
| Klíčová slova | JAK2; JAK2(V617F) |
| Popis | Philadelphia chromosome–negative myeloproliferative neoplasms (MPNs) can be viewed as clonal premalignant disorders that precede development of acute leukemia wherein the order of mutation acquisition, together with environmental insults such as inflammation, matters. MPN disease-defining somatic mutations are in Janus kinase 2 (JAK2), calreticulin (CALR), and myeloproliferative leukemia virus oncogene (MPL; a gene encoding thrombopoietin receptor) genes. |