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Macrolide resistance in yaws

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ŠMAJS David POSPÍŠILOVÁ Petra

Rok publikování 2018
Druh Článek v odborném periodiku
Časopis / Zdroj Lancet
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www http://dx.doi.org/10.1016/S0140-6736(18)30205-8
Doi http://dx.doi.org/10.1016/S0140-6736(18)30205-8
Klíčová slova Macrolide resistance
Popis The study by Oriol Mitja and colleagues in The Lancet shows that a single round of mass administration of azithromycin is insufficient to achieve yaws eradication. It also represents the first report of a mutation in both 23S rRNA genes of the yaws-causing spirochaete, Treponema pallidum subspecies pertenue (T p pertenue), causing macrolide resistance in five epidemiologically linked patients. The mutation, A2059G, was previously reported in a patient with syphilis (caused by T p pallidum) with spiramycin treatment failure;2 it is one of two macrolide-resistant mutations previously detected in T p pallidum (the other is A2058G). Since its discovery, the A2059G mutation has been detected in T p pallidum isolates from patients with syphilis from Argentina,China, Czech Republic,the UK, Madagascar and the USA.

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