Zde se nacházíte:
Informace o publikaci
Online solid-phase extraction liquid chromatography-mass spectrometry of hair cortisol using a surrogate analyte
Autoři | |
---|---|
Rok publikování | 2019 |
Druh | Článek v odborném periodiku |
Časopis / Zdroj | Chemical Papers |
Fakulta / Pracoviště MU | |
Citace | |
www | https://link.springer.com/article/10.1007/s11696-018-0560-1 |
Doi | http://dx.doi.org/10.1007/s11696-018-0560-1 |
Klíčová slova | Endogenous cortisol; Long-term hair concentration; Surrogate analyte LC–MS; Online SPE |
Popis | Online SPE LC–MS with 13C3-cortisol as a surrogate analyte was developed, validated and applied for obtaining hair cortisol levels of 114 healthy volunteers. The first 3 cm from a posterior vertex position were analyzed as three individual segments resulting in 310 hair cortisol levels, which were used, after log transformation, to predict a range of values observed in future. The median value of hair cortisol was 4.76 pg/mg. The employed method allowed simple processing, high throughput and may be readily expanded to analyze additional steroid compounds in hair. |
Související projekty: |