Informace o publikaci
Transgenerational phenotype aggravation in CAF-1 mutants reveals parent-of-origin specific epigenetic inheritance
| Název česky | Mezigenerační zhoršování fenotypu v CAF-1 mutantech odhaluje epigenetickou dědičnost závislou na rodiči-původci |
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| Autoři | |
| Rok publikování | 2018 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | New Phytologist |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | http://www.newphytologist.com |
| Doi | http://dx.doi.org/10.1111/nph.15082 |
| Klíčová slova | Arabidopsis thaliana; CAF-1; Chromatin; Development; DNA methylation; epigenetics; histone |
| Popis | Shoot- and root-related growth phenotypes were progressively more affected in successive generations of CAF-1 mutants. Early and late generations of the fasciata (fas)2-4 CAF-1 mutant displayed only limited changes in gene expression, of which increasing upregulation of plant defense-related genes reflects the transgenerational phenotype aggravation. Likewise, global DNA methylation in the sequence context CHG but not CG or CHH (where H = A, T or C) changed over generations in fas2-4. Crossing early and late generation fas2-4 plants established that the maternal contribution to the phenotype severity exceeds the paternal contribution. |
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