Informace o publikaci

MyocardialT(1)mapping using SMART(1)Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis

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PANOVSKÝ Roman DOUBKOVÁ Martina HOLEČEK Tomáš MÁCHAL Jan FEITOVÁ Věra MASÁROVÁ Lucia OPATŘIL Lukáš MOJICA-PISCIOTTI Mary Luz KINCL Vladimír

Rok publikování 2020
Druh Článek v odborném periodiku
Časopis / Zdroj NMR in Biomedicine
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://onlinelibrary.wiley.com/doi/10.1002/nbm.4388
Doi http://dx.doi.org/10.1002/nbm.4388
Klíčová slova cardiac magnetic resonance; extracellular volume; parametric mapping; sarcoidosis
Popis Introduction Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement ofT(1)relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assessT(1)mapping in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods One hundred and twenty patients with extracardiac sarcoidosis and without any heart disease history were included. One hundred and thirteen of them underwent a CMR examination. The mean time from the diagnosis of sarcoidosis was 0.8 (0.2-3.3) years. Cine images for the assessment of left ventricular (LV) functional parameters and pre- and post-contrast saturation method using adaptive recovery times for cardiacT(1)mapping (SMART(1)Map) and modified Look-Locker inversion recovery (MOLLI) images were acquired for the assessment of nativeT(1)relaxation time and extracellular volume (ECV). The measured parameters were compared between sarcoidosis patients and 22 controls. Results The sarcoidosis patients had normal global and regional systolic LV function-LV ejection fraction 65 +/- 5% versus 66 +/- 7% (pNS). The mean nativeT(1)relaxation times were not prolonged-1465 +/- 93 ms versus 1480 +/- 88 ms (pNS) measured by SMART(1)Map and 1317 +/- 60 ms versus 1313 +/- 83 ms (pNS) measured using a MOLLI sequence. Similarly, the mean ECV values did not increase-16.9 +/- 3.9% versus 17.9 +/- 3.7% (pNS) measured by SMART(1)Map and 30.9 +/- 2.9% versus 31.6 +/- 8.3% (pNS) measured using a MOLLI sequence. Conclusion Myocardial nativeT(1)relaxation times were not prolonged and ECV was not increased in asymptomatic patients with extracardiac sarcoidosis.
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