Informace o publikaci

Blood pressure excursions in acute ischemic stroke patients treated with intravenous thrombolysis

Autoři	TSIVGOULIS G. KATSANOS A. H. MANDAVA P. KOHRMANN M. SOINNE L. BARRETO A. D. SHARMA V. K. MIKULÍK Robert MUIR K. W. ROTHLISBERGER T. GROTTA J. C. LEVI C. R. MOLINA C. A. SAQQUR M. MAVRIDIS D. PSALTOPOULOU T. VOSKO M. R. FIEBACH J. B. SANDSET E. C. KENT T. A. ALEXANDROV A. W. SCHELLINGER P. D. ALEXANDROV A. V.
Rok publikování	2021
Druh	Článek v odborném periodiku
Časopis / Zdroj	Journal of Hypertension
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://journals.lww.com/jhypertension/Fulltext/2021/02000/Blood_pressure_excursions_in_acute_ischemic_stroke.11.aspx
Doi	http://dx.doi.org/10.1097/HJH.0000000000002628
Klíčová slova	blood pressure; intracranial hemorrhage; monitoring; outcome; sonothrombolysis; stroke; thrombolysis
Popis	Objective: To investigate the association of blood pressure BP excursions, defined as greater than 185 SBP or greater than 105 DBP, with the probability of intracranial hemorrhage (ICH) and worse functional outcomes in patients with acute ischemic stroke (AIS) treated with tissue plasminogen activator (tPA). Methods: We performed a post hoc analysis of the CLOTBUST-ER trial. Serial BP measurements were conducted using automated cuff recording according to the recommended BP protocol guidelines for tPA administration. The outcomes were prespecified efficacy and safety endpoints of CLOTBUST-ER. Results: The mean number of serial BP recordings per patient was 37. Of the 674 patients, 227 (34%) had at least one BP excursion (>185/105 mmHg) during the first 24 h following tPA-bolus. The majority of BP excursions (46%) occurred within the first 75min from tPA-bolus. Patients with at least one BP excursion in the first 24 h following tPA bolus had significantly lower rates of independent functional outcome at 90 days (31 vs. 40.1%, P = 0.028). The total number of BP excursions was associated with decreased odds of 24-h clinical recovery (OR = 0.88, 95% CI:0.80-0.96), 24-h neurological improvement (OR = 0.87, 95% CI: 0.81-0.94), 7-day functional improvement (common OR = 0.92, 95% CI: 0.87-0.97), 90-day functional improvement (common OR = 0.94, 95% CI: 0.88-0.98) and 90-day independent functional outcome (OR = 0.90, 95% CI: 0.82-0.98) in analyses adjusted for potential confounders. DBP excursions were independently associated with increased odds of any intracranial hemorrhage (OR = 1.26, 95% CI: 1.04-1.53). Conclusion: BP excursions above guideline thresholds during the first 24 h following tPA administration for AIS are common and are independently associated with adverse clinical outcomes.