Informace o publikaci

Voiding recovery after radical parametrectomy in cervical cancer patients: An international prospective multicentre trial - SENTIX

Autoři	ZAPARDIEL I. KOCIAN Roman KOHLER C. KLAT Jaroslav GERMANOVA Anna JACOB A. BAJSOVA Sylva BOHMER G. LAY L. GIL-IBANEZ B. HAVELKA Pavel KIPP B. SZEWCZYK G. TOTH R. STARINGER J. C. DE SANTIAGO J. CORONADO P. J. POKA R. LAKY R. LUYCKX M. FASTREZ M. DUŠEK Ladislav HERNANDEZ A. CIBULA David
Rok publikování	2021
Druh	Článek v odborném periodiku
Časopis / Zdroj	Gynecologic Oncology
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.sciencedirect.com/science/article/pii/S0090825820342219?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.ygyno.2020.12.018
Klíčová slova	Radical hysterectomy; Parametrectomy; Cervical cancer; Voiding recovery; Nerve-sparing techniques
Popis	OBJECTIVE: Voiding dysfunctions represent a leading morbidity after radical hysterectomy performed in patients with early-stage cervical cancer. The aim of this study was to perform ad hoc analysis of factors influencing voiding recovery in SENTIX (SENTinel lymph node biopsy in cervIX cancer) trial. METHODS: The SENTIX trial (47 sites, 18 countries) is a prospective study on sentinel lymph node biopsy without pelvic lymphadenectomy in patients with early-stage cervical cancer. Overall, the data of 300 patients were analysed. Voiding recovery was defined as the number of days from surgery to bladder catheter/epicystostomy removal or to post-voiding urine residuum <= 50 mL. RESULTS: The median voiding recovery time was three days (5th-95th percentile: 0-21): 235 (78.3%) patients recovered in <7 days and 293 (97.7%) in 30 days. Only seven (2.3%) patients recovered after 0.001) significantly influenced voiding recovery 7 days post-surgery. Type-B parametrectomy was associated with a higher risk of delayed voiding recovery than type-C1 (OR = 4.69; p = 0.023 vs. OR = 3.62; p = 0.052, respectively), followed by type-C2 (OR = 5.84; p = 0.011). Both previous pregnancy and type C2 parametrectomy indepen-dently prolonged time to voiding recovery by two days. CONCLUSIONS: Time to voiding recovery is significantly related to previous pregnancy and type of parametrectomy but it is not influenced by surgical approach (open vs minimally invasive), age, or BMI. Type B parametrectomy, without direct visualisation of nerves, was associated with longer recovery than nerve-sparing type C1. Importantly, voiding dysfunctions after radical surgery are temporary, and the majority of the patients recover in less than 30 days, including patients after C2 parametrectomy. (C) 2020 Elsevier Inc. All rights reserved.