Informace o publikaci

A cellular and spatial map of the choroid plexus across brain ventricles and ages

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NEIL Dani HERBST Rebecca H. MCCABE Cristin GREEN Gilad S. KAISER Karol HEAD Joshua P. CUI Jin SHIPLEY Frederick B. JANG Ahram DIONNE Danielle NGUYEN Lan RODMAN Christopher RIESENFELD Samantha J. PROCHAZKA Jan PROCHAZKOVA Michaela SEDLACEK Radislav ZHANG Feng BRYJA Vítězslav ROZENBLATT-ROSEN Orit HABIB Naomi REGEV Aviv LEHTINEN Maria K

Rok publikování 2021
Druh Článek v odborném periodiku
Časopis / Zdroj Cell
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.1016/j.cell.2021.04.003
Doi http://dx.doi.org/10.1016/j.cell.2021.04.003
Klíčová slova choroid plexus; brain barrier; cerebrospinal fluid; single-cell RNA sequencing; single-nucleus RNA sequencing; aging; development
Popis The choroid plexus (ChP) in each brain ventricle produces cerebrospinal fluid (CSF) and forms the blood-CSF barrier. Here, we construct a single-cell and spatial atlas of each ChP in the developing, adult, and aged mouse brain. We delineate diverse cell types, subtypes, cell states, and expression programs in epithelial and mesenchymal cells across ages and ventricles. In the developing ChP, we predict a common progenitor pool for epithelial and neuronal cells, validated by lineage tracing. Epithelial and fibroblast cells show regionalized expression by ventricle, starting at embryonic stages and persisting with age, with a dramatic transcriptional shift with maturation, and a smaller shift in each aged cell type. With aging, epithelial cells upregulate host-defense programs, and resident macrophages upregulate interleukin-1 beta (IL-1 beta) signaling genes. Our atlas reveals cellular diversity, architecture and signaling across ventricles during development, maturation, and aging of the ChP-brain barrier.
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