Informace o publikaci
Antimicrobial and enzyme inhibitory activities of the constituents of Plectranthus madagascariensis (Pers.) Benth
| Autoři | |
|---|---|
| Rok publikování | 2014 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | Journal of Enzyme Inhibition and Medicinal Chemistry |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://pubmed.ncbi.nlm.nih.gov/24506206/ |
| Doi | http://dx.doi.org/10.3109/14756366.2013.848204 |
| Klíčová slova | alpha-glucosidase; antibacterial activity; cholinesterase; diterpenoids; rosmarinic acid |
| Popis | Plectranthus madagascariensis is used as a traditional medicine in Southern Africa. In search of compounds and activities supporting the medicinal use, the chemical profile of the methanolic extract was studied by high-performance liquid chromatography with diode array detection (HPLC-DAD). Four major constituents were isolated and identified as rosmarinic acid (1), 7 beta, 6 beta-dihydroxyroyleanone (2), 7 beta-acetoxy-6 beta-hydroxyroyleanone (3) and coleon U quinone (4). The two abietane diterpenoids (2 and 3) were isolated for the first time from this species. Antimicrobial, cholinesterase and alpha-glucosidase inhibitory activities of these compounds were studied. The compounds exhibited inhibitory activity on alpha-glucosidase with IC50 values from 33 to 275 mu M. Abietanes showed potent antibacterial activity against Staphylococcus aureus and Enterococcus faecalis. |