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Somatic Mutations in Exon 7 of the TP53 Gene in Index Colorectal Lesions Are Associated with the Early Occurrence of Metachronous Adenoma

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HÁLKOVÁ Tereza PTÁČKOVÁ Renata SEMYAKINA Anastasiya SUCHÁNEK Štěpán TRABOULSI Eva NGO Ondřej HEJCMANOVÁ Kateřina MÁJEK Ondřej BUREŠ Jan ZAVORAL Miroslav MINÁRIK Marek BENEŠOVÁ Lucie

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Cancers
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.mdpi.com/2072-6694/14/12/2823
Doi http://dx.doi.org/10.3390/cancers14122823
Klíčová slova colorectal cancer; colorectal adenomas; colonoscopy; index lesion; synchronous lesion; metachronous lesion; tumor heterogeneity; TP53
Popis (1) Background: this prospective study was focused on detailed analysis of the mutation heterogeneity in colorectal lesions removed during baseline (index) colonoscopy to identify patients at high risk of early occurrence of metachronous adenomas. (2) Methods: a total of 120 patients after endoscopic therapy of advanced colorectal neoplasia size ?10 mm (index lesion) with subsequent surveillance colonoscopy after 10–18 months were included. In total, 143 index lesions and 84 synchronous lesions in paraffin blocks were divided into up to 30 samples. In each of them, the detection of somatic mutations in 11 hot spot gene loci was performed. Statistical analysis to correlate the mutation profiles and the degree of heterogeneity of the lesions with the risk of metachronous adenoma occurrence was undertaken. (3) Results: mutation in exon 7 of the TP53 gene found in the index lesion significantly correlated with the early occurrence of metachronous adenoma (log-rank test p = 0.003, hazard ratio 2.73, 95% confidence interval 1.14–6.56). We did not find an association between the risk of metachronous adenomas and other markers monitored. (4) Conclusions: the findings of this study could lead to an adjustment of existing recommendations for surveillance colonoscopies in a specific group of patients with mutations in exon 7 of the TP53 gene in an index lesion, where a shortening of surveillance interval may be warranted.
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