Informace o publikaci
Purification of human telomerase TEN domain and its interaction partner TPP1
| Autoři | |
|---|---|
| Rok publikování | 2018 |
| Druh | Článek ve sborníku |
| Konference | 15 th International Interdisciplinary Meeting on Bioanalysis |
| Fakulta / Pracoviště MU | |
| Citace | |
| www | https://www.ce-ce.org/ |
| Klíčová slova | TELOMERASE; TPP1; SHELTERIN |
| Popis | The telomerase adds telomeric repeats to chromosome ends to act against telomere shortening. Telomerase activation contributes to the immortality of cancer cells. Therefore, telomerase inhibition is an attractive target for cancer therapy. In this study we show initial results of preparation of recombinant construct of TEN domain from human telomerase and human protein TPP1 from shelterin complex, which is responsible for telomerase recruitment to telomeres and promotion of an effective DNA synthesis. |
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