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Effect of Bisphenol S on testicular tissue after low-dose lactation exposure

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FENCLOVÁ Tereza CHEMEK Marouane HAVRÁNKOVÁ Jiřina KOLINKO Yaroslav SUDOVÁ Vendula MORAVEC Jiří NAVRÁTILOVÁ Jana KLEIN Pavel KRÁLÍČKOVÁ Milena NEVORAL Jan

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Environmental Pollution
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://doi.org/10.1016/j.envpol.2022.120114
Doi http://dx.doi.org/10.1016/j.envpol.2022.120114
Klíčová slova Bisphenol S; Idiopathic infertility; Lactation exposure; Testicular tissue; Blood -testis barrier; Oxidative stress
Popis Exposure to endocrine disruptors such as bisphenols, can lead to and be the explanation for idiopathic infertility. In our study, we assessed the effect of exposure to bisphenol S (BPS) via breast milk on the testicular tissue health of adult male mice. Lactating dams were exposed to BPS through drinking water (0.216?ng?g bw/day and 21.6?ng?g bw/day) from post-natal day 0–15. Although there was no significant difference in testicular histopathology between the control and experimental groups, we observed an increase in the number of tight and gap junctions in the blood-testis barrier (BTB) of adult mice after lactation BPS exposure. Moreover, there was an increase in oxidative stress markers in adult testicular tissue of mice exposed via breast milk. Our lactation model indicates that breast milk is a route of exposure to an endocrine disruptor that can be responsible for idiopathic male infertility through the damage of the BTB and weakening of oxidative stress resistance in adulthood.
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