Informace o publikaci

Age-Related Effects of COVID-19 Pandemic on Mechanical Reperfusion and 30-Day Mortality for STEMI: Results of the ISACS-STEMI COVID-19 Registry

Autoři	GIUSEPPE De Luca ALGOWHARY Magdy UGUZ Berat OLIVEIRA Dinaldo C GANYUKOV Vladimir BUSLJETIK Oliver CERCEK Miha JENSEN Lisette Okkels LOH Poay Huan CALMAC Lucian FERRER Gerard Roura i QUADROS Alexandre MILEWSKI Marek UCCIO Fortunato Scotto CLEMENS von Birgelen VERSACI Francesco JURRIEN Ten Berg CASELLA Gianni LUNG Aaron Wong Sung KALA Petr GIL Jose Luis Diez CARRILLO Xavier DIRKSEN Maurits MUNOZ Victor Becerra LEE Michael Kang-yin JUZAR Dafsah Arifa JOAQUIM Rodrigo de Joaquim PALADINO Roberto MILICIC Davor DAVLOUROS Periklis BAKRACESKI Nikola ZILIO Filippo DONAZZAN Luca KRAAIJEVELD Adriaan GALASSO Gennaro ARPAD Lux MARINUCCI Lucia GUIDUCCI Vincenzo MENICHELLI Maurizio SCOCCIA Alessandra YAMAC Aylin Hatice MERT Kadir Ugur RIOS Xacobe Flores KOVARNIK Tomas KIDAWA Michal MOREU Jose FLAVIEN Vincent FABRIS Enrico MARTINEZ-LUENGAS Inigo Lozano BOCCALATTE Marco OJEDA Francisco Bosa ARELLANO-SERRANO Carlos CAIAZZO Gianluca CIRRINCIONE Giuseppe KAO Hsien-Li FORES Juan Sanchis VIGNALI Luigi PEREIRA Helder MANZO-SILBERMAN Stephane ORDONEZ Santiago ALEV Arat Ozkan SCHELLER Bruno LEHITOLA Heidi TELES Rui MANTIS Christos ANTTI Ylitalo SILVEIRA Joao Antonio Brum ZONI Cesar Rodrigo BESSONOV Ivan UCCELLO Giuseppe KOCHIADAKIS George ALEXOPULOS Dimitrios URIBE Carlos E KANAKAKIS John FAURIE Benjamin GABRIELLI Gabriele BARRIOS Alejandro Gutierrez BACHINI Juan Pablo ROCHA Alex TAM Frankie C C RODRIGUEZ Alfredo LUKITO Antonia Anna SAINT-JOY Veauthyelau PESSAH Gustavo TUCCILLO Andrea IELASI Alfonso CORTESE Giuliana PARODI Guido BURGADHA Mohammed Abed KEDHI Elvin LAMELAS Pablo SURYAPRANATA Harry NARDIN Matteo VERDOIA Monica
Rok publikování	2023
Druh	Článek v odborném periodiku
Časopis / Zdroj	Journal of Clinical Medicine
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://www.mdpi.com/2077-0383/12/6/2116
Doi	http://dx.doi.org/10.3390/jcm12062116
Klíčová slova	ageing; ST-segment elevation myocardial infarction; COVID-19
Popis	Background: The constraints in the management of patients with ST-segment elevation myocardial infarction (STEMI) during the COVID-19 pandemic have been suggested to have severely impacted mortality levels. The aim of the current analysis is to evaluate the age-related effects of the COVID-19 pandemic on mechanical reperfusion and 30-day mortality for STEMI within the registry ISACS-STEMI COVID-19. Methods: This retrospective multicenter registry was performed in high-volume PPCI centers on four continents and included STEMI patients undergoing PPCI in March-June 2019 and 2020. Patients were divided according to age (< or >= 75 years). The main outcomes were the incidence and timing of PPCI, (ischemia time longer than 12 h and door-to-balloon longer than 30 min), and in-hospital or 30-day mortality. Results: We included 16,683 patients undergoing PPCI in 109 centers. In 2020, during the pandemic, there was a significant reduction in PPCI as compared to 2019 (IRR 0.843 (95%-CI: 0.825-0.861, p < 0.0001). We found a significant age-related reduction (7%, p = 0.015), with a larger effect on elderly than on younger patients. Furthermore, we observed significantly higher 30-day mortality during the pandemic period, especially among the elderly (13.6% vs. 17.9%, adjusted HR (95% CI) = 1.55 [1.24-1.93], p < 0.001) as compared to younger patients (4.8% vs. 5.7%; adjusted HR (95% CI) = 1.25 [1.05-1.49], p = 0.013), as a potential consequence of the significantly longer ischemia time observed during the pandemic. Conclusions: The COVID-19 pandemic had a significant impact on the treatment of patients with STEMI, with a 16% reduction in PPCI procedures, with a larger reduction and a longer delay to treatment among elderly patients, which may have contributed to increase in-hospital and 30-day mortality during the pandemic.