Informace o publikaci
5′-UTR mRNA splicing determines CD20 levels
Autoři | |
---|---|
Rok publikování | 2023 |
Druh | Článek v odborném periodiku (nerecenzovaný) |
Fakulta / Pracoviště MU | |
Citace | |
Přiložené soubory | |
Popis | In this issue of Blood, Ang et al(1) show that human CD20 messenger RNA (mRNA) undergoes alternative splicing to generate distinct 5' untranslated region (5'-UTR) variants, which determine the cell-surface CD20 levels in malignant B cells and the interpatient variability in the expression of this therapeutic target. These variants can also be used as an escape mechanism from anti-CD20 therapies. |
Související projekty: |