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Non-invasive temporal interference electrical stimulation of the human hippocampus

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VIOLANTE Ines R ALANIA Ketevan CASSARA Antonino M NEUFELD Esra ACERBO Emma CARRON Romain WILLIAMSON Adam KURTIN Danielle L RHODES Edward HAMPSHIRE Adam KUSTER Niels BOYDEN Edward S PASCUAL-LEONE Alvaro GROSSMAN Nir

Rok publikování 2023
Druh Článek v odborném periodiku
Časopis / Zdroj Nature Neuroscience
Fakulta / Pracoviště MU

Lékařská fakulta

Citace
www https://www.nature.com/articles/s41593-023-01456-8
Doi http://dx.doi.org/10.1038/s41593-023-01456-8
Klíčová slova human hippocampus; electrical stimulation
Popis Deep brain stimulation (DBS) via implanted electrodes is used worldwide to treat patients with severe neurological and psychiatric disorders. However, its invasiveness precludes widespread clinical use and deployment in research. Temporal interference (TI) is a strategy for non-invasive steerable DBS using multiple kHz-range electric fields with a difference frequency within the range of neural activity. Here we report the validation of the non-invasive DBS concept in humans. We used electric field modeling and measurements in a human cadaver to verify that the locus of the transcranial TI stimulation can be steerably focused in the hippocampus with minimal exposure to the overlying cortex. We then used functional magnetic resonance imaging and behavioral experiments to show that TI stimulation can focally modulate hippocampal activity and enhance the accuracy of episodic memories in healthy humans. Our results demonstrate targeted, non-invasive electrical stimulation of deep structures in the human brain.

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