Informace o publikaci

A preliminary choroid plexus volumetric study in individuals with psychosis

Autoři	SENAY Olcay SEETHALER Magdalena MAKRIS Nikos YETERIAN Edward RUSHMORE Jarrett CHO Kang Ik K RIZZONI Elizabeth HELLER Carina PASTERNAK Ofer SZCZEPANKIEWICZ Filip WESTIN Carl-Frederik LOŠÁK Jan USTOHAL Libor TOMANDL Josef VOJTÍŠEK Lubomír KUDLIČKA Petr KIKINIS Zora HOLT Daphne LEWANDOWSKI Kathryn E LIZANO Paulo KESHAVAN Matcheri S ONGUR Dost KAŠPÁREK Tomáš BREIER Alan SHENTON Martha E SEITZ-HOLLAND Johanna KUBICKI Marek
Rok publikování	2023
Druh	Článek v odborném periodiku
Časopis / Zdroj	Human Brain mapping
Fakulta / Pracoviště MU	Lékařská fakulta
Citace
www	https://onlinelibrary.wiley.com/doi/10.1002/hbm.26224
Doi	http://dx.doi.org/10.1002/hbm.26224
Klíčová slova	cerebrospinal fluid; manual segmentation; neuroinflammation; perivascular space; schizophrenia; ventricle
Popis	The choroid plexus (ChP) is part of the blood-cerebrospinal fluid barrier, regulating brain homeostasis and the brain's response to peripheral events. Its upregulation and enlargement are considered essential in psychosis. However, the timing of the ChP enlargement has not been established. This study introduces a novel magnetic resonance imaging-based segmentation method to examine ChP volumes in two cohorts of individuals with psychosis. The first sample consists of 41 individuals with early course psychosis (mean duration of illness = 1.78 years) and 30 healthy individuals. The second sample consists of 30 individuals with chronic psychosis (mean duration of illness = 7.96 years) and 34 healthy individuals. We utilized manual segmentation to measure ChP volumes. We applied ANCOVAs to compare normalized ChP volumes between groups and partial correlations to investigate the relationship between ChP, LV volumes, and clinical characteristics. Our segmentation demonstrated good reliability (.87). We further showed a significant ChP volume increase in early psychosis (left: p < .00010, right: p < .00010) and a significant positive correlation between higher ChP and higher LV volumes in chronic psychosis (left: r = .54, p = .0030, right: r = .68; p < .0010). Our study suggests that ChP enlargement may be a marker of acute response around disease onset. It might also play a modulatory role in the chronic enlargement of lateral ventricles, often reported in psychosis. Future longitudinal studies should investigate the dynamics of ChP enlargement as a promising marker for novel therapeutic strategies.