Informace o publikaci

Changes of serum protein N-glycosylation in cancer

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BENEŠOVÁ Iva URMINSKÝ Adam Paulin HALÁMKOVÁ Jana HERNYCHOVÁ Lenka

Rok publikování 2022
Druh Článek v odborném periodiku
Časopis / Zdroj Časopis Klinická onkologie
Citace
www https://www.linkos.cz/files/klinicka-onkologie/505/6058.pdf
Doi http://dx.doi.org/10.48095/ccko2022174
Klíčová slova glycommics; glycoproteomics; N-glycans; N-glycan profiling; glycopeptides; serum proteins;, mass spectrometry
Popis Glycosylation is a posttranslantional modification responsible for many biological processes including protein-protein interactions, cell signaling or cell cycle regulation. Changes in glycosylation of serum proteins reflects the status od tissues and cells in the organism and therefore can be used as markers for diagnosis of cancer, its progression and determination of its subtypes. N-glycan profiling is often used for characterization of N- glycosylation changes. It is based on the measurements of N-glycans released from the serum proteins. Beside the N-glycan profiling, glycoproteomic approach is emerging as it preserves the information about glycan composition, original protein, and its glycosylation sites. Purpose: This review covers existing works describing the changes in serum protein N-glycosylation in various cancer types. Attention was paid to both the glycomic and glycoproteomic approaches. The last part of the review shortly presents the analytical methods used for these analyses.

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