Informace o publikaci

Anticholinesterase Activity of Methanolic Extract of Amorpha fruticosa Flowers and Isolation of Rotenoids and Putrescine and Spermidine Derivatives

Logo poskytovatele
Autoři

JANKOVSKÁ Dagmar JURČOVÁ Nikol KUBÍNOVÁ Renata VÁCLAVÍK Jiří ŠVAJDLENKA Emil MASCELLANI Anna MARSIK Petr BOUZKOVÁ Kateřina MALANÍK Milan

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj PLANTS-BASEL
Fakulta / Pracoviště MU

Farmaceutická fakulta

Citace
www https://pubmed.ncbi.nlm.nih.gov/38732396/
Doi http://dx.doi.org/10.3390/plants13091181
Klíčová slova AChE; Amorpha fruticosa; BuChE; molecular docking; putrescine; spermidine
Popis Five putrescine and spermidine derivatives (1-5) together with five rotenoids (6-10) were isolated from a methanolic extract of the flowers of A. fruticosa that displayed promising inhibition of 76.0 +/- 1.9% for AChE and 90.0 +/- 4.0% for BuChE at a concentration of 1 mg/mL. Although the anticholinesterase activities of the isolated compounds did not reach that of galantamine, molecular docking revealed that all-trans-tri-p-coumaroylspermidine and trans-trans-cis-tri-p-coumaroylspermidine showed binding poses mimicking the known inhibitor galantamine and thus could serve as model molecules in future searches for new AChE and BuChE inhibitors.
Související projekty:

Používáte starou verzi internetového prohlížeče. Doporučujeme aktualizovat Váš prohlížeč na nejnovější verzi.

Další info