Informace o publikaci

Detrimental consequences of micropolymers associated plasticizers on endocrinal disruption

Autoři	SAHA Utsa KUMARI Puja GHOSH Aishee SINHA Adrija JENA Snehasmita KIRTI Apoorv GUPTA Abha CHOUDHURY Anmol SIMNANI Faizan Zareen NANDI Aditya SAHOO Rudra Narayan KUMARI Shalini MISHRA Richa KAUSHIK Nagendra Kumar SINGH Deobrat SUAR Mrutyunjay VERMA Suresh K.
Rok publikování	2024
Druh	Článek v odborném periodiku
Časopis / Zdroj	Materials Today Bio
Fakulta / Pracoviště MU	Přírodovědecká fakulta
Citace
www	https://www.sciencedirect.com/science/article/pii/S2590006424001984?via%3Dihub
Doi	http://dx.doi.org/10.1016/j.mtbio.2024.101139
Klíčová slova	Microplastic; Nanoplastic; Plasticizers; Hormones; Endocrine disrupting chemical; Hypothalamus -pituitary axis
Popis	The prevalence of polymer usage in everyday activities has emerged as a detriment to both human life and the environment. A large number of studies describe severe impacts of micropolymers (MP) and nanopolymers (NP) on various organ systems, including the endocrine system. Additionally, plasticizers utilized as additives have been identified as endocrine-disrupting chemicals (EDCs). MP/NP, along with associated plasticizers, affect principal signalling pathways of endocrine glands such as the pituitary, thyroid, adrenal, and gonads, thereby disrupting hormone function and metabolic processes crucial for maintaining homeostasis, fertility, neural development, and fetal growth. This review delves into the sources, distribution, and effects of micropolymers, nanopolymers, and associated plasticizers acting as EDCs. Furthermore, it provides a detailed review of the mechanisms underlying endocrine disruption in relation to different types of MP/NP.