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Luminescent photon-upconversion nanoparticles with advanced functionalization for smart sensing and imaging

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SKLÁDAL Petr FARKA Zdeněk

Rok publikování 2024
Druh Článek v odborném periodiku
Časopis / Zdroj Microchimica Acta
Fakulta / Pracoviště MU

Přírodovědecká fakulta

Citace
www https://link.springer.com/article/10.1007/s00604-024-06615-7
Doi http://dx.doi.org/10.1007/s00604-024-06615-7
Klíčová slova Fluorescent dyes; Resonance energy transfer; Bioconjugates; Intracellular biosensor; Nanosensor
Popis Photon-upconversion nanoparticles (UCNP) have already been established as labels for affinity assays in analog and digital formats. Here, advanced, or smart, systems based on UCNPs coated with active shells, fluorescent dyes, and metal and semiconductor nanoparticles participating in energy transfer reactions are reviewed. In addition, switching elements can be embedded in such assemblies and provide temporal and spatial control of action, which is important for intracellular imaging and monitoring activities. Demonstration and critical comments on representative approaches demonstrating the progress in the use of such UCNPs in bioanalytical assays, imaging, and monitoring of target molecules in cells are reported, including particular examples in the field of cancer theranostics.
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