Informace o publikaci
Early-stage laryngeal carcinoma treated in the Oncology centre of Saint Anne’s University Hospital and Masaryk Memorial Cancer Institute in Brno in years 2016-2018; 22nd Czech - German ENT Days 13 - 14 September 2024; Prague
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| Rok publikování | 2024 |
| Druh | Další prezentace na konferencích |
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| Popis | Introduction Squamous cell carcinoma of the larynx is a malignant tumour arising from the squamous epithelium of the larynx and is the 23rd most common malignancy. In the Czech Republic, laryngeal carcinoma was diagnosed in 518 patients in 2016, 533 patients in 2017, and 452 patients in 2018. Methods In this retrospective analysis, we studied patients with early-stage glottic laryngeal carcinoma (Tis-T2N0M0), thus patients in clinical stage 0, 1 and 2. A total of 44 patients treated between 2016 and 2018 in the Oncology Centre of St. Anne’s University Hospital and Masaryk Memorial Cancer Institute in Brno with this extent of involvement were included. The study compared the outcomes of first-line oncological treatment, including surgical and non-surgical modalities, recurrence timing, disease-free interval, and five-year survival rates. Results Out of these 44 patients, 22 were treated surgically in Saint Anne’s University Hospital. No recurrences were observed among these patients, and 7 patients died from causes other than the cancer. Treatment for 22 patients was provided in the Masaryk Memorial Cancer Institute in Brno. Of these 22 patients, 20 underwent curative radiotherapy with a total dose of 70 Gy, while 2 patients received concurrent therapy, with one patient completing 2 cycles and the other 3 cycles of cisplatin. Among 8 patients who received primary non-surgical treatment, recurrence was confirmed and leading to total laryngectomy for each. Of these patients, 7 died, with one death attributed to the underlying condition – verrucous type carcinoma. Conclusion Surgical treatment of early-stage laryngeal carcinoma demonstrates high efficacy with no recurrences in our patient cohort, with mortality due to causes other than the cancer itself. In contrast, patients receiving non-surgical treatment have a higher risk of recurrence, leading to more subsequent surgeries, including total laryngectomy. Specific challenges in treatment are associated particularly with the verrucous type of carcinoma. |