Informace o publikaci
High-throughput sequencing of Strongyloides stercoralis – a fatal disseminated infection in a dog
| Autoři | |
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| Rok publikování | 2024 |
| Druh | Článek v odborném periodiku |
| Časopis / Zdroj | PARASITOLOGY |
| Citace | |
| www | https://www.cambridge.org/core/journals/parasitology/article/highthroughput-sequencing-of-strongyloides-stercoralis-a-fatal-disseminated-infection-in-a-dog/E085E2C44E784F4EEA6DAEFF5E23199B#article |
| Doi | http://dx.doi.org/10.1017/S0031182024000568 |
| Klíčová slova | dog; high-throughput sequencing; Strongyloides stercoralis; Strongyloidiasis; zoonotic |
| Popis | The rhabditid nematode Strongyloides stercoralis is known worldwide as the causative agent of strongyloidiasis in humans. In addition to public health concerns, S. stercoralis also infects dogs, which represent a possible reservoir for potentially zoonotic transmissions. We describe the first confirmed case of fatal disseminated infection in a dog in the Czech Republic. The microscopic and histological results were supported by a complex genotyping approach. Using high-throughput sequencing of the hypervariable region (HVR-IV) of 18S rDNA and Sanger sequencing of the partial cytochrome c oxidase subunit 1 gene (cox1), the potentially zoonotic haplotype/lineage A of S. stercoralis was confirmed, while the solely canine haplotype/lineage B was not found. The development of the disease is mainly associated with immunodeficiency, and in this case, it was triggered by inappropriate treatment, in particular the use of corticosteroids. |
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