Informace o publikaci
Circulating plasma cells in multiple myeloma
| Název česky | Cirkulující plazmatické buňky u mnohočetného myelomu |
|---|---|
| Autoři | |
| Rok publikování | 2024 |
| Druh | Konferenční abstrakty |
| Citace | |
| Popis | Multiple myeloma (MM) is a hemato-oncological disease characterized by abnormal plasma cell (PCs) proliferation. In MM, these PCs proliferate within the bone marrow, leading to bone destruction, bone marrow failure, and the secretion of abnormal proteins into the bloodstream. However, in some cases of MM, these PCs can escape from the bone marrow microenvironment and enter the bloodstream. The presence of circulating PCs (cPCs) in peripheral blood is considered a sign of advanced or aggressive disease. It may also indicate disease progression or relapse in patients who have previously undergone treatment. We investigated differences in microRNA (miRNA) expression between bone marrow plasma cells (BMPCs) and cPCs of MM patients. Samples of BMPCs (N = 33) and cPCs (N = 13) were subjected to next generation sequencing, enabling comprehensive profiling of miRNA expression patterns. Our analysis revealed four significantly (P < 0.0000000001) differentially expressed miRNAs between BMPCs and cPCs. These findings suggest distinct molecular profiles between BMPCs and cPCs, indicating potential differences in the regulatory mechanisms underlying MM progression at different anatomical sites. Further exploration of these miRNAs may unveil their roles in MM pathogenesis and offer new potential therapeutic targets or biomarkers |