Informace o publikaci
Pentamethinium Salts, New Inhibitors of Cancer Cell Migration
| Autoři | |
|---|---|
| Rok publikování | 2022 |
| Druh | Další prezentace na konferencích |
| Fakulta / Pracoviště MU | |
| Citace | |
| Popis | In solid tumors, invasiveness and metastasis contribute to over 90% of cancer-related deaths. Despite advancements in cancer treatment, effective drugs specifically targeting these processes remain unavailable. While cytostatic therapies aim to inhibit tumor cell growth and division, migrastatic treatments focus on preventing cell movement, local invasion, and metastasis. The most effective approach would likely involve a combination of both strategies. Pentamethinium salts (PMS) are a class of fluorescent compounds with varying cytotoxicity, depending on their molecular structure, that can influence tumor cell migration. Certain fluorescent dyes from the pentamethinium family demonstrate high affinity and specificity for cardiolipin in the inner mitochondrial membrane, offering excellent photostability, strong fluorescence properties, and low phototoxicity. At nanomolar concentrations, these dyes enable selective imaging of mitochondria in both live and fixed cells across different cell lines. Their minimal toxicity and precise localization allow for the study of mitochondrial morphology, structural complexity, and dynamics, which are crucial in various pathological conditions. This study aims to confirm the migrastatic potential of selected pentamethinium salts. Future research will focus on validating these findings in vivo, with the hypothesis that administering these compounds could prevent metastasis in a murine model of mammary carcinoma. |